BDBM31545 Milciclib::pyrazolo[4,3-h]quinazoline-3-carboxamide, 28

SMILES: CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21

InChI Key: InChIKey=RXZMYLDMFYNEIM-UHFFFAOYSA-N

Data: 23 IC50  5 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 31545   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 5 activator 1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 4 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Wee1-like protein kinase (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 5 activator 1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	7.4	23
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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Wee1-like protein kinase 2 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
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Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a
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Wee1-like protein kinase (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 2 [596-900] (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	672	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	398	n/a	n/a	n/a	n/a	n/a	25
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	363	n/a	n/a	n/a	n/a	n/a	25
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Aurora kinase A (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	25
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High affinity nerve growth factor receptor (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	53	n/a	n/a	n/a	n/a	7.5	23
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	7.4	23
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Cyclin-dependent kinase 5 activator 1 (Human)	BDBM31545 (Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	265	n/a	n/a	n/a	n/a	7.4	23
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