BDBM316983 N-[3-(4-Chloro-7H- pyrrolo[2,3-d]pyrimidine-5- carbonyl)-2,4-difluoro- phenyl]-5-propyl- benzenesulfonamide::US9617267, Compound P-1034

SMILES CCCc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncnc(Cl)c23)c1F

InChI Key InChIKey=WLPFZVLMFBVNJD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 316983   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Plexxikon

US Patent
LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Plexxikon

US Patent
LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
Plexxikon

US Patent
LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Plexxikon

US Patent
LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Plexxikon

US Patent
LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Plexxikon

US Patent
LigandPNGBDBM316983(US9617267, Compound P-1034 | N-[3-(4-Chloro-7H- py...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent