BDBM318034 8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]methyl]piperazin-1-yl]- 3,5,6,7-tetrahydropyrido[2,3- d]pyrimidin-4-one dihydrochloride::US9624218, Example 35::US9624218, Example 36

SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1

InChI Key: InChIKey=VLKQIEMXMFAOES-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 318034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Human)	BDBM318034 (US9624218, Example 35 | 8-Methyl-2-[4-[[3-trifluor...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Human)	BDBM318034 (US9624218, Example 35 | 8-Methyl-2-[4-[[3-trifluor...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.54	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Human)	BDBM318034 (US9624218, Example 35 | 8-Methyl-2-[4-[[3-trifluor...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Human)	BDBM318034 (US9624218, Example 35 | 8-Methyl-2-[4-[[3-trifluor...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM318034 (US9624218, Example 35 | 8-Methyl-2-[4-[[3-trifluor...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair