BDBM33394 2,4-diaminofuro[2,3-d]pyrimidine, 1a::E-isomer

SMILES COc1ccccc1\C(C)=C\c1coc2nc(N)nc(N)c12

InChI Key InChIKey=JXICVPBZQSPDOK-VQHVLOKHSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 33394   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.28E+4nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.03E+4nMAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  7.70E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.64E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.85E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  1.45E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM33394(2,4-diaminofuro[2,3-d]pyrimidine, 1a | E-isomer)
Affinity DataIC50:  4.00E+3nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed