BDBM339612 US10202339, Compound 56
SMILES Fc1ccc(NC(=O)Nc2cc(ccc2-c2cccnc2)S(=O)(=O)NCC(F)(F)F)cc1C(F)(F)F
InChI Key InChIKey=LTPRJNNXUNTPRT-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 339612
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Homo sapiens (Human))
Agios Pharmaceuticals
US Patent
Agios Pharmaceuticals
US Patent
Affinity DataIC50: 5.50E+3nMAssay Description:Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...More data for this Ligand-Target Pair