BDBM344785 2-{3-[1-(2-fluorophenyl)-::2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimidazolidin-1-yl}-N-[(3S)-tetrahydrofuran-3-yl]acetamide::US9783527, Example 87

SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(CC(=O)N[C@H]2CCOC2)C1=O

InChI Key InChIKey=ROCRDDYVKPYLHQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 344785   

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM344785(2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimi...)
Affinity DataIC50: 2.46E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

LigandPNGBDBM344785(2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimi...)
Affinity DataIC50: 5.56E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent