BDBM354328 1-(1-(3-((Dimethylphosphoryl)methyl)phenyl)-3-isopropyl-1H-pyrazol-5-yl)-3-(4-((2-((3-ethynyl-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9796742, Example 56

SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OCCN5CCOCC5)cc(c4)C#C)n3)c3ccccc23)n(n1)-c1cccc(CP(C)(C)=O)c1

InChI Key InChIKey=JQOGWYYYHFQUHH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354328   

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM354328(1-(1-(3-((Dimethylphosphoryl)methyl)phenyl)-3-isop...)
Affinity DataIC50: 788nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
Entry Details
US Patent