BDBM362347 N-(3-(7-(1H-indol-2-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)phenyl)acrylamide ::US9834551, Example 3

SMILES C=CC(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cc5ccc(Cl)cc5[nH]4)c3n2)c1

InChI Key InChIKey=ZMVOCEZRJJVAOX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362347   

TargetTyrosine-protein kinase JAK3(Human)
Arrien Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 362347BDBM362347(US9834551, Example 3 | N-(3-(7-(1H-indol-2-yl)-5H-...)
Affinity DataIC50: 100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Arrien Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 362347BDBM362347(US9834551, Example 3 | N-(3-(7-(1H-indol-2-yl)-5H-...)
Affinity DataIC50: 100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent