BDBM364538 N-(3-Hydroxy-3-methyl-butyl)-4-methyl-3-{6-[3-methyl-1-(2-morpholin-4-yl-ethyl)-1H-pyrazol-4-yl]-pyrazin-2-yl}-benzenesulfonamide::US9862711, Example 10

SMILES Cc1nn(CCN2CCOCC2)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O

InChI Key InChIKey=BVUXORJTWQTUTI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 364538   

LigandPNGBDBM364538(US9862711, Example 10 | N-(3-Hydroxy-3-methyl-buty...)
Affinity DataIC50: 20nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364538(US9862711, Example 10 | N-(3-Hydroxy-3-methyl-buty...)
Affinity DataIC50: 27nMAssay Description:PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, US...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364538(US9862711, Example 10 | N-(3-Hydroxy-3-methyl-buty...)
Affinity DataIC50: 70nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364538(US9862711, Example 10 | N-(3-Hydroxy-3-methyl-buty...)
Affinity DataIC50: 8.50E+3nMAssay Description:PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, US...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM364538(US9862711, Example 10 | N-(3-Hydroxy-3-methyl-buty...)
Affinity DataIC50: 9.80E+3nMAssay Description:mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM364538(US9862711, Example 10 | N-(3-Hydroxy-3-methyl-buty...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364538(US9862711, Example 10 | N-(3-Hydroxy-3-methyl-buty...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent