BDBM371204 4-(Cyclopropanecarbonyl)-N-(1-methylcyclopropyl)-2-[(3-methylisoxazol-5-yl)methyl]-1-oxo-isoquinoline-7-sulfonamide::US10239843, Example 311

SMILES Cc1cc(Cn2cc(C(=O)C3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)on1

InChI Key InChIKey=IDFPLLUXTURGIG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371204   

TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371204(4-(Cyclopropanecarbonyl)-N-(1-methylcyclopropyl)-2...)
Affinity DataIC50:  549nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371204(4-(Cyclopropanecarbonyl)-N-(1-methylcyclopropyl)-2...)
Affinity DataIC50: >1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetADP-ribosylhydrolase ARH3(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371204(4-(Cyclopropanecarbonyl)-N-(1-methylcyclopropyl)-2...)
Affinity DataIC50: >1.50E+5nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent