BDBM378953 2-{1-(2,6- dichloro-3- (trifluoromethyl) benzyl]-1H- indazol-3-yl}-5- methoxy-N- (pyridin-4- yl)pyrimidin-4- amine::US10266548, Example 2-34-1

SMILES COc1cnc(-c2nn(Cc3c(Cl)ccc(C(F)(F)F)c3Cl)c3ccccc23)nc1NC1=CCNC=C1

InChI Key InChIKey=MLSQBNAEAJLLEA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378953   

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Bayer Intellectual Property

US Patent
LigandChemical structure of BindingDB Monomer ID 378953BDBM378953(US10266548, Example 2-34-1 | 2-{1-(2,6- dichloro-3...)
Affinity DataIC50: 38nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent