BDBM387818 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10294226, Compound Ex. 1::US10487083, Example 1::US10981911, Example 1::US11059823, Example 1

SMILES: CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1

InChI Key: InChIKey=NJKMSBSVJSQUBU-UHFFFAOYSA-N

Data: 24 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 387818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Mouse)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	299	n/a	n/a	n/a	n/a	n/a	n/a
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JAK3/JAK1 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	257	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [512-1124] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	87.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [532-1132] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [574-1154] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [580-1182] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [512-1124] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [532-1132] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [574-1154] (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM387818 (US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair