BDBM395934 US10308660, Example 10

SMILES Cn1c(nc(N)c(Sc2cccc(c2)C#N)c1=O)N1CCC(C)(CN)CC1

InChI Key InChIKey=CREXSXYZOXVTIK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 395934   

LigandPNGBDBM395934(US10308660, Example 10)
Affinity DataIC50: 5.63E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent