BDBM406679 US10336752, Compound 17::US10968236, Compound I-63::US11040967, Compound 17

SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cc2)C(=O)N2C[C@@H]3COC[C@@H]3C2)c2C(=O)NCc2n1

InChI Key InChIKey=ODBNOQBNPBRPNZ-IYBDPMFKSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 406679   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM406679(US10336752, Compound 17 | US10968236, Compound I-6...)
Affinity DataKi: <10nMAssay Description:Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM406679(US10336752, Compound 17 | US10968236, Compound I-6...)
Affinity DataKi:  55nMAssay Description:Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM406679(US10336752, Compound 17 | US10968236, Compound I-6...)
Affinity DataIC50:  88.6nMAssay Description:Compounds were serially diluted in DMSO then further diluted in 1× kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM406679(US10336752, Compound 17 | US10968236, Compound I-6...)
Affinity DataIC50:  88.6nMAssay Description:Compounds were serially diluted in DMSO then further diluted in 1x kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent