BDBM413083 6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-1-yl)-N-(2-(1-methylpyrrolidin-2-yl)ethyl)nicotinamide::US10407409, Example 23::US10407409, Example 31

SMILES COc1cc(ccn1)-c1cnn(c1O)-c1ccc(cn1)C(=O)NCCC1CCCN1C

InChI Key InChIKey=CIPNKELDPBULJU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 413083   

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413083(US10407409, Example 31 | 6-(5-hydroxy-4-(2-methoxy...)
Affinity DataIC50: 31.6nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413083(US10407409, Example 31 | 6-(5-hydroxy-4-(2-methoxy...)
Affinity DataIC50: 126nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent