BDBM413450 7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one::US10407446, Example 3::US11136340, Example 3
SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
InChI Key InChIKey=XISVSTPEXYIKJL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 43 hits for monomerid = 413450
Affinity DataIC50: 5.01E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculovirus expression...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PI3Kdelta in human JeKo1 cells assessed as reduction in anti-human IgM-induced AKT phosphorylation at T208 residue preincubated for 1 h...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to full-length human His-tagged p110delta/p85alpha expressed in baculovirus expression system mea...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant full-length human His-tagged p110gamma expressed in baculovirus expression system ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibition of ATM in human HT-29 cells assessed as reduction in irradiation-induced autophosphorylation at Ser1981 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >8.30E+3nMAssay Description:Inhibition of PDK1 in human BT474c cells assessed as reduction in AKT phosphorylation at T208 residueMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PI3Kbeta in human MDA-MB-468 cells assessed as reduction in AKT phosphorylation at T208 residue measured after 2 hrs by QuantaBlu subst...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mus musculus (Mouse))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264 cells assessed as reduction in C5a anaphylatoxin trifluoroacetate salt-induced AKT phosphorylation at T208 re...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.631nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human full-length GST-tagged TTK expressed in baculovirus expression system measur...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant full-length human His-tagged p110beta/p85alpha expressed in baculovirus expression...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >1.98E+5nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -90 mV holding potential by electrophysiological assayMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in bacul...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to human untagged DNA-PK expressed in baculovirus expression system measured after 60 mins by Lan...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of PI3Kalpha in human BT474c cells assessed as reduction in AKT phosphorylation at T208 residue measured after 2 hrs by QuantaBlu substrat...More data for this Ligand-Target Pair
Affinity DataIC50: >2.90E+4nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as reduction in 4NQO-induced CHK1 phosphorylation at S345 residue preincubated for 1 hr followed by 4...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in radiation-induced autophosphorylation at S2056 residue preincubated for 1 hr follow...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.631nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 5.01E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreenŽ Eu Kinase Binding assay run by ThermoFisher Scientific as part of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human native full length DNA-PK by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 187nMAssay Description:Inhibition of human PI3Kalpha by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of human PI3Kbeta by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 363nMAssay Description:Inhibition of human PI3Kgamma by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 973nMAssay Description:Inhibition of human PI3Kdelta by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of hERG expressed in CHO cells by electrophysiological assay based automated patch clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair