BDBM413614 5-[(2-{4-[5-Chloro-2-(1,3-oxazol-5-yl)phenyl]-5-methoxy-2-oxopyridin-1(2H)-yl}-4-methoxybutanoyl)amino]-N-methylpyridine-2-carboxamide (Racemate)::US10421742, Example 10::US11180471, Example 10

SMILES CNC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(cc2=O)-c2cc(Cl)ccc2-c2cnco2)cn1

InChI Key InChIKey=BVTWDIIYCUBXNG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 413614   

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM413614(5-[(2-{4-[5-Chloro-2-(1,3-oxazol-5-yl)phenyl]-5-me...)
Affinity DataIC50: 4nMAssay Description:FXIa: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM413614(5-[(2-{4-[5-Chloro-2-(1,3-oxazol-5-yl)phenyl]-5-me...)
Affinity DataIC50: 4nMAssay Description:The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM413614(5-[(2-{4-[5-Chloro-2-(1,3-oxazol-5-yl)phenyl]-5-me...)
Affinity DataIC50: 21nMAssay Description:To determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM413614(5-[(2-{4-[5-Chloro-2-(1,3-oxazol-5-yl)phenyl]-5-me...)
Affinity DataIC50: 21nMAssay Description:Plasma Kallikrein: Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent