BDBM417540 2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-yl}-1- oxo-2,3-dihydro-1H- isoindol-2-yl)-N- (oxan-4-yl) acetamide::US10457669, Example 154::US11001575, Example 154

SMILES Clc1cnc(NC2CCOCC2)nc1-c1ccc2CN(CC(=O)NC3CCOCC3)C(=O)c2c1

InChI Key InChIKey=IVVWOBYHSJPKCL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417540   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417540(2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-y...)
Affinity DataIC50: 14nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417540(2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-y...)
Affinity DataIC50: 14nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent