BDBM418543 5-Fluoro-6-[7-methoxy-3- methyl-8-(1-methyl-1H- pyrazol-4-yl)-2-oxo-2,3- dihydroimidazo[4,5-c]- quinolin-1-yl]-N-methyl- nicotinamid::US10457677, Example 138::US10975075, Example 138::US11608338, Example 138

SMILES CNC(=O)c1cnc(c(F)c1)-n1c2c(cnc3cc(OC)c(cc23)-c2cnn(C)c2)n(C)c1=O

InChI Key InChIKey=BTDJPGOFUSLMSZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418543   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418543(5-Fluoro-6-[7-methoxy-3- methyl-8-(1-methyl-1H- py...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418543(5-Fluoro-6-[7-methoxy-3- methyl-8-(1-methyl-1H- py...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418543(5-Fluoro-6-[7-methoxy-3- methyl-8-(1-methyl-1H- py...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent