BDBM419984 US10472364, Compound 60::US10570167, Cpd. # 60::US11034715, Cpd. # 75::US11208414, Cpd. # 60

SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(c(F)c2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F

InChI Key InChIKey=DQDBOICWIDYVNT-DDFXLWFNSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 419984   

Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  51nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  512nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  51nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  51nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  512nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  512nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  990nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  51nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM419984(US10472364, Compound 60 | US10570167, Cpd. # 60 | ...)
Affinity DataIC50:  887nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent