BDBM433145 N-((1R,3r,5S)-8-((1,7- diazaspiro[3.5]nonan-7-yl)sulfonyl)-8- azabicyclo[3.2.1]octan-3-yl)-5- cyclopropylisoxazole-3-carboxamide::US10577363, Compound 849

SMILES O=C(N[C@@H]1C[C@@H]2CC[C@H](C1)N2S(=O)(=O)N1CCC2(CCN2)CC1)c1cc(on1)C1CC1

InChI Key InChIKey=RYQBXHIJJBMTNX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433145   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM433145(US10577363, Compound 849 | N-((1R,3r,5S)-8-((1,7- ...)
Affinity DataIC50: 5.95nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent