BDBM451746 6-(2-amino-5-(thiazolo[4,5- c]pyridin-7-yl)pyridin-3-yl)- 3,4-dihydroisoquinolin-1(2H)- one::US10710978, Compound I-56

SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cncc2ncsc12

InChI Key InChIKey=YLERTVWFPXCRBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451746   

TargetSerine/threonine-protein kinase 4(Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 451746BDBM451746(6-(2-amino-5-(thiazolo[4,5- c]pyridin-7-yl)pyridin...)
Affinity DataIC50: 550nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase 26(Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 451746BDBM451746(6-(2-amino-5-(thiazolo[4,5- c]pyridin-7-yl)pyridin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase 3(Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 451746BDBM451746(6-(2-amino-5-(thiazolo[4,5- c]pyridin-7-yl)pyridin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase 24(Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 451746BDBM451746(6-(2-amino-5-(thiazolo[4,5- c]pyridin-7-yl)pyridin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent