BDBM47423 2-[(E)-2-phenylethenyl]-2,3-dihydropyran-6-one::2-[(E)-styryl]-2,3-dihydropyran-6-one::MLS000574880::SMR000156256::cid_5317826

SMILES CC[C@@H]1CCC[C@@]1(N)COc4cc(c2cnc3cccc(OC)n23)cc(SC)c4C#N

InChI Key InChIKey=RLGHFVLWYYVMQZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 47423   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47423BDBM47423(US20240124450, Example 10A)
Affinity DataIC50: 3.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47423BDBM47423(US20240124450, Example 10A)
Affinity DataIC50: 5.30nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47423BDBM47423(US20240124450, Example 10A)
Affinity DataIC50: 16.4nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent