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BDBM50001634 8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octanoic acid::CHEMBL135612

SMILES: CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O

InChI Key: InChIKey=WFPFILGYCCUVGQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50001634   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LTB4R


(Homo sapiens (Human))
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001634
PNG
(8-(4,6-Diphenyl-pyridin-2-yloxy)-2,2-dimethyl-octa...)
Show SMILES CC(C)(CCCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H31NO3/c1-27(2,26(29)30)17-11-3-4-12-18-31-25-20-23(21-13-7-5-8-14-21)19-24(28-25)22-15-9-6-10-16-22/h5-10,13-16,19-20H,3-4,11-12,17-18H2,1-2H3,(H,29,30)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair