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BDBM50006352 3'-amino-1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,2',5(3'H)-trione::CHEMBL65472

SMILES: NN1C(=O)Nc2ccccc2C11NC(=O)NC1=O

InChI Key: InChIKey=YYQPNSRPIWZGMS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006352   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006352
PNG
(3'-amino-1'H,2H,5H-spiro[imidazolidine-4,4'-quinaz...)
Show SMILES NN1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C10H9N5O3/c11-15-9(18)12-6-4-2-1-3-5(6)10(15)7(16)13-8(17)14-10/h1-4H,11H2,(H,12,18)(H2,13,14,16,17)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair