BDBM50006490 (+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acid::(-)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acid::(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acid::CHEMBL303218

SMILES C[C@@H]1C[C@@](O)(CC(O)=O)c2cc(F)c(Cl)cc2O1

InChI Key InChIKey=BRXHBAFNICPNFH-SREIQFSDSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50006490   

TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  46nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  49nMAssay Description:ARI(aldose reductase inhibitor) enantiospecificity against human placental aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  12nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  60nMAssay Description:ARI(aldose reductase inhibitor) enantiospecificity against human placental aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed