BDBM50009001 5,6,7-Trihydroxyflavone::5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one::Baicalein::Baicalein, 14::Baicalein, 8::CHEMBL8260::US10252984, Table 2.33
SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
InChI Key InChIKey=FXNFHKRTJBSTCS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 89 hits for monomerid = 50009001
Affinity DataKi: 260nMAssay Description:Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufinMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:Inhibition of human 15-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.22E+3nMAssay Description:Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufinMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataKi: 1.60E+3nMAssay Description:Inhibition of human platelet-type 12-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataKi: 4.33E+3nMAssay Description:Non-competitive inhibition of JMJD2E relative to alpha-ketoglutarateMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30E+3nMpH: 7.45 T: 2°CAssay Description:Inhibition assay of human testes mcrosomal 17 beta-hydroxysteroid dehydrogenase for the reduction of androstenedione.More data for this Ligand-Target Pair
TargetLinoleate 9S-lipoxygenase-4(Glycine max (Soybean) (Glycine hispida))
Pcsir Laboratories Complex
Pcsir Laboratories Complex
Affinity DataIC50: 2.20E+4nMpH: 8.0 T: 2°CAssay Description:LOX inhibiting activity was measured by modifying the spectrophotometric method developed by Tappel. More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMpH: 8.0 T: 2°CAssay Description:All reactions were carried in a volume of 2 mL stirred at 23°C with approximately 2.040 Units of 12-hLOX, 4.200 Units of 15-hLOX-1, and 6.600 Un...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.15E+4nMpH: 7.5 T: 2°CAssay Description:All reactions were carried in a volume of 2 mL stirred at 23°C with approximately 2.040 Units of 12-hLOX, 4.200 Units of 15-hLOX-1, and 6.600 Un...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago De Chile
Universidad De Santiago De Chile
Affinity DataIC50: 7.10E+4nMpH: 7.5 T: 2°CAssay Description:All reactions were carried in a volume of 2 mL stirred at 23°C with approximately 2.040 Units of 12-hLOX, 4.200 Units of 15-hLOX-1, and 6.600 Un...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:H-DXR was pre-incubated during 2 min in the presence of the inhibitors at different concentrations and DXP (480 µM). NADPH (160 µM final concentratio...More data for this Ligand-Target Pair
Affinity DataIC50: 4.06E+3nMAssay Description:The kinase assay was performed using the EMD Millipore KinaseProfiler service assay protocol. Aurora B kinase was supplied by EMD Millipore Corp. The...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago De Chile
Universidad De Santiago De Chile
Affinity DataIC50: >1.00E+5nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
Affinity DataIC50: 850nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+5nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.26E+4nMpH: 8.0 T: 2°CAssay Description:A mixture of test compound (10 μL; 1 mM) in MeOH, type-1B lipoxygenase (EC 1.13.11.12; from soyabean) (20 μL; 70 units) in 0.1 M aqueous ph...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rattus norvegicus)
Institute For Bio-Medical Research
Curated by ChEMBL
Institute For Bio-Medical Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibitory activity of the compound against 12-lipoxygenase in rat platelet rich plasmaMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Institute For Bio-Medical Research
Curated by ChEMBL
Institute For Bio-Medical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity of the compound against 5-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rattus norvegicus)
Institute For Bio-Medical Research
Curated by ChEMBL
Institute For Bio-Medical Research
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibitory activity of the compound against 15-lipoxygenase in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavageMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human intestinal sucrase in human Caco2 cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JMJD2EMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of recombinant HIV-1 integrase 3'-processing activity using 32P 5' end-labeled linear 21'mer as substrate preincubated for 30 mins prior t...More data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activity using 32P 5' end-labeled linear 21'mer as substrate preincubated for 30 mins prior...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of His6-tagged HIV-1 integrase assessed as decrease in integrase-Flag-LEDGF/p75 interaction preincubated with enzyme for 30 mins followed ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago De Chile
Universidad De Santiago De Chile
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Dalian University Of Technology
Curated by ChEMBL
Dalian University Of Technology
Curated by ChEMBL
Affinity DataIC50: 6.53E+3nMAssay Description:Inhibition of Cdk1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: >3.50E+5nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target4-aminobutyrate aminotransferase, mitochondrial(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: 1.28E+7nMAssay Description:Inhibition of GABA transaminase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.86E+5nMAssay Description:Inhibition of 17beta-HSD3More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Human Genome Research Institute
Curated by ChEMBL
National Human Genome Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+5nMAssay Description:Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recerca BiomèDica De Barcelona
Curated by ChEMBL
Institut De Recerca BiomèDica De Barcelona
Curated by ChEMBL
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Institut De Recerca BiomèDica De Barcelona
Curated by ChEMBL
Institut De Recerca BiomèDica De Barcelona
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of rat intestinal sucrase expressed in human Caco2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of cow milk xanthine oxidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of human Neu2 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase integrationMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of sucraseMore data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Indian Institute Of Chemical Technology
Curated by ChEMBL
Indian Institute Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of maltaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of rat intestinal sucraseMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Dongguk University-Seoul
Curated by ChEMBL
Dongguk University-Seoul
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Institute For Bio-Medical Research
Curated by ChEMBL
Institute For Bio-Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of LTB4 production was measured in rat bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in KB/MDR cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.03E+4nMAssay Description:Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayMore data for this Ligand-Target Pair