BDBM50009859 (+-)-2-(p-isobutylphenyl)propionic acid::(+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid::(+-)-ibuprofen::(+-)-p-isobutylhydratropic acid::(4-isobutylphenyl)-alpha-methylacetic acid::(RS)-ibuprofen::2-(4-isobutylphenyl)propanoic acid::2-[4-(2-methylpropyl)phenyl]propanoic acid::4-isobutylhydratropic acid::Advil::Brufen::CHEMBL521::IBUPROFEN LYSINE::Ibuprofen::Ibuprofen (1)::Motrin::alpha-(4-isobutylphenyl)propionic acid::alpha-(p-isobutylphenyl)propionic acid
SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
InChI Key InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 159 hits for monomerid = 50009859
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
Affinity DataKi: 3.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKi: 4.70E+3nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of sheep placental cotyledons COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of sheep placental cotyledons COX1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 4.76E+4nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
Affinity DataKi: 5.00E+4nMAssay Description:Binding affinity measured on human cytochrome P450 2C9 (CYP2C9) enzymeMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1A1(Rattus norvegicus)
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataKi: 1.26E+5nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.64E+5nM ΔG°: -9.27kcal/moleT: 2°CAssay Description:Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following...More data for this Ligand-Target Pair
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 4.48E+5nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...More data for this Ligand-Target Pair
Affinity DataKi: 5.60E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.17E+6nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cellsMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1A4(Rattus norvegicus)
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataKi: 2.43E+6nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin uptake in Oatp2-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+14nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 8.00E+3nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataIC50: 7.60E+3nMAssay Description:The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+4nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+5nMpH: 7.0 T: 2°CAssay Description:Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+5nMpH: 7.0 T: 2°CAssay Description:Frozen (−80°C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+3nMAssay Description:Concentration (in microM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substr...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysateMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoa...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Concentration (in microM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandinMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver estera...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver est...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Faculdade de Ci�ncias e Tecnologia-UNL
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro inhibitory concentration of the compound against COX-2 enzymeMore data for this Ligand-Target Pair