BDBM50010052 2-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide::CHEMBL440134

SMILES O=S1(=O)N(CCCCN2CCC(=CC2)c2ccccc2)c2cccc3cccc1c23

InChI Key InChIKey=OKJRBFNMYSRTKZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010052   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
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Curated by ChEMBL
LigandPNGBDBM50010052(2-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Affinity DataIC50:  7.80nMAssay Description:The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
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Curated by ChEMBL
LigandPNGBDBM50010052(2-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Affinity DataIC50:  2.10nMAssay Description:The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
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Curated by ChEMBL
LigandPNGBDBM50010052(2-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Affinity DataIC50:  55nMAssay Description:The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed