BDBM50010736 CHEMBL78083::N,N'-Bis-(4-ethyl-phenyl)-guanidine

SMILES CCc1ccc(NC(N)=Nc2ccc(CC)cc2)cc1

InChI Key InChIKey=DXGARAMIKHFTJV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010736   

TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010736(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Affinity DataIC50:  245nMAssay Description:Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010736(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Affinity DataIC50:  1.39E+3nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50010736(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Affinity DataIC50:  245nMAssay Description:In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed