BDBM50015306 CHEMBL3263842

SMILES COc1cc(cc(OC)c1OC)C(=O)N[C@@H](C(C)C)c1nc(cs1)C(=O)Nc1ccccc1C(=O)c1ccccc1

InChI Key InChIKey=VUSXKXGCZNKQFS-SANMLTNESA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50015306   

TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50015306(CHEMBL3263842)
Affinity DataEC50:  27nMAssay Description:Stimulation of ATPase activity of ABCB1 (unknown origin) expressed in High Five insect cell membrane assessed as ATP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50015306(CHEMBL3263842)
Affinity DataIC50:  720nMAssay Description:Displacement of [125I]IAPP from ABCB1 (unknown origin) expressed in High Five insect cell membrane at >5 uM preincubated for 10 mins by autoradiograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50015306(CHEMBL3263842)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human wild type P-gp expressed in BacMam virus infected human HeLa cells assessed as calcein-AM accumulation after 10 mins by flow cyto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed