BDBM50016703 2-Hydroxymethyl-pyrrolidine-3,4-diol::BDBM50031485::CHEMBL80254::Imino-D-Arabinitol

SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O

InChI Key InChIKey=OQEBIHBLFRADNM-ZZKAVYKESA-N

Data  3 KI  29 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50016703   

TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataKi:  400nMAssay Description:Inhibitory activity against pig Liver glycogen phosphorylase aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
Universit£

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataKi:  400nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase using tritium-labeled glycogen as substrate by scintillation counterMore data for this Ligand-Target Pair
TargetAlpha-mannosidase 2(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataKi:  3.50E+4nMAssay Description:Competitive Inhibitory activity against Golgi Alpha-mannosidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrehalase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of lysosomal Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2C1(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL62(Saccharomyces cerevisiae)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  840nMAssay Description:Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of rat intestinal maltase assessed as glucose release by Glucose B-testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of rat intestinal sucrase assessed as glucose release by Glucose B-testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of rat intestinal isomaltase assessed as glucose release by Glucose B-testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-mannosidase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of rat epididymis beta-mannosidase assessed as p-nitrophenol release by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2C1(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucoamylase, intracellular sporulation-specific(Saccharomyces cerevisiae S288c)
Universit£

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  150nMAssay Description:Inhibition of yeast alpha-D-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of rat intestinal maltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of rat sucraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of rat isomaltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen debranching enzyme(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen debranching enzyme(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of rat intestinal maltase assessed as release of D-glucose using maltose as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of rat intestinal sucrase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-mannosidase(Canavalia ensiformis)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of rat small intestinal maltase assessed as reduction of D-glucose release using maltose as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of rat small intestinal sucrase assessed as reduction of p-nitrophenol release using p-nitrophenyl-glycoside as substrate by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMaltase-glucoamylase(Homo sapiens)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of human lysosomal alpha-glucosidase assessed as reduction of p-nitrophenol release using p-nitrophenyl-glycoside as substrate by spectrop...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLactase/phlorizin hydrolase(Rattus norvegicus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  2.60E+5nMAssay Description:Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase(Canavalia ensiformis)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  4.74E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase assessed as reduction of p-nitrophenol release using p-nitrophenyl-glycoside as substrate by spectrophotome...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed