BDBM50026941 8-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL57364

SMILES Clc1cccc(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1

InChI Key InChIKey=ATIJQZLSMDZBIR-UHFFFAOYSA-N

Data  4 KI  1 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50026941   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50026941(8-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C21H28ClN3O2/c22-17-4-3-5-18(14-17)24-11-8-23(9-12-24)10-13-25-19(26)15-21(16-20(25)27)6-1-2-7-21/h3-5,14H,1-2,6-13,15-16H2
Affinity DataKi:  1.09nMAssay Description:Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli...More data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50026941(8-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C21H28ClN3O2/c22-17-4-3-5-18(14-17)24-11-8-23(9-12-24)10-13-25-19(26)15-21(16-20(25)27)6-1-2-7-21/h3-5,14H,1-2,6-13,15-16H2
Affinity DataKi:  2.02nMAssay Description:Binding affinity to the adrenergic receptor alpha-1D of rat aortaMore data for this Ligand-Target Pair
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50026941(8-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C21H28ClN3O2/c22-17-4-3-5-18(14-17)24-11-8-23(9-12-24)10-13-25-19(26)15-21(16-20(25)27)6-1-2-7-21/h3-5,14H,1-2,6-13,15-16H2
Affinity DataKi:  221nMAssay Description:Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleenMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Recordati S.p.A.

Curated by ChEMBL
LigandPNGBDBM50026941(8-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C21H28ClN3O2/c22-17-4-3-5-18(14-17)24-11-8-23(9-12-24)10-13-25-19(26)15-21(16-20(25)27)6-1-2-7-21/h3-5,14H,1-2,6-13,15-16H2
Affinity DataKi: >1.00E+3nMAssay Description:In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens.More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026941(8-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C21H28ClN3O2/c22-17-4-3-5-18(14-17)24-11-8-23(9-12-24)10-13-25-19(26)15-21(16-20(25)27)6-1-2-7-21/h3-5,14H,1-2,6-13,15-16H2
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair