BDBM50030764 CHEMBL3342187

SMILES NCc1ccc(OCCCc2sc(nc2C(O)=O)-c2ccc3CCC\C(=N/Nc4nc5ccccc5s4)c3c2)cc1

InChI Key InChIKey=JKMWZKPAXZBYEH-JWHWKPFMSA-N

Data  1 KI  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50030764   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataKi:  1.10nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of biotinylated BIM BH3 26-mer peptide binding to GST-tagged Bcl-xL (unknown origin) pre-incubated for 30 mins followed by peptide additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataEC50:  48nMAssay Description:Inhibition of BCL-XL (unknown origin) expressed in mcl-1 deficient MEF assessed as induction of cell killing in presence of 10% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed