BDBM50032631 CHEMBL3354192

SMILES COC1CCN(CC1)c1nccc(Nc2cc3c(n[nH]c3cn2)C(C)C)n1

InChI Key InChIKey=GKMHWPHQBQHBKR-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50032631   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032631(CHEMBL3354192)
Affinity DataKi:  18nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) by high-throughput biochemical screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032631(CHEMBL3354192)
Affinity DataKi:  42nMAssay Description:Inhibition of EGFR T790M/del746 to 750 mutant (unknown origin) by high-throughput biochemical screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032631(CHEMBL3354192)
Affinity DataKi:  611nMAssay Description:Inhibition of wild-type EGFR (unknown origin) by high-throughput biochemical screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032631(CHEMBL3354192)
Affinity DataIC50:  476nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032631(CHEMBL3354192)
Affinity DataIC50:  2.24E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032631(CHEMBL3354192)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50032631(CHEMBL3354192)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Jak2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed