BDBM50033731 (R)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione::5,8-Dihydroxy-2-((R)-1-hydroxy-4-methyl-pent-3-enyl)-[1,4]naphthoquinone::5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[1,4]naphthoquinone::CHEMBL9470::Shikonin

SMILES: CC(C)C=CC(=O)c1cc(O)c2c(O)ccc(O)c2c1O

InChI Key: InChIKey=FSWBAMMIGFKJBV-UHFFFAOYSA-N

Data: 42 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50033731   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 1 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 3 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sterol O-acyltransferase 2 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sterol O-acyltransferase 1 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	301	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	381	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	326	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
COP9 signalosome complex subunit 5 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
COP9 signalosome complex subunit 5 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus (strain A/Brevig Mission/1/1918 ...)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase 1 (Baker's yeast)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sortase family protein (Staphylococcus aureus)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sortase family protein (Staphylococcus aureus)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKM (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 1 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pyruvate kinase PKLR (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase SETD7 (Human)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50033731 (5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair