BDBM50034939 6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL53903

SMILES COc1ccc(NCc2cnc3nc(N)nc(N)c3c2C)c2ccccc12

InChI Key InChIKey=WRDIIGHJSQOTJF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50034939   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034939(6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-meth...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034939(6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-meth...)
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034939(6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-meth...)
Affinity DataIC50: 41nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034939(6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-meth...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034939(6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-meth...)
Affinity DataIC50: 54nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034939(6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-meth...)
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed