BDBM50063984 5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidine-2,4-diamine::5-(Naphthalen-1-ylsulfanylmethyl)-furo[2,3-d]pyrimidine-2,4-diamine::CHEMBL283515

SMILES Nc1nc(N)c2c(CSc3cccc4ccccc34)coc2n1

InChI Key InChIKey=VOFSSRGYMNQZKV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50063984   

TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063984(5-((naphthalen-1-ylthio)methyl)furo[2,3-d]pyrimidi...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed