BDBM50070798 CHEMBL3409256

SMILES NC(=O)c1ccccc1OCCCN1CCN(CC1)c1cccc2n(ccc12)S(=O)(=O)c1ccccc1

InChI Key InChIKey=KWZBJWOQFABHPF-UHFFFAOYSA-N

Data  15 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50070798   

TargetD(3) dopamine receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]methylspiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]methylspiperone from human D2S receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]N-methylspiperone from human recombinant dopamine D2 receptor expressed in CHOK1 cells incubated for 60 mins by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]methylspiperone from human dopamine D4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]pirenzepine from human muscarinic M1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]imipramine from human SERT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]mesulergine from human 5-HT2C receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells assessed as reduction in channel current at holding potential of 0 mV by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopmaine D3 receptor expressed in CHOK1 cells assessed as effect on cAMP levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University Collegium Medicum

Curated by ChEMBL
LigandPNGBDBM50070798(CHEMBL3409256)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human recombinant dopmaine D2L receptor expressed in CHOK1 cells assessed as intracellular Ca2+ levels by aequorin based radiomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed