BDBM50071374 Basimglurant::RG-7090::RO-4917523

SMILES Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1

InChI Key InChIKey=UPZWINBEAHDTLA-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50071374   

TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)
Affinity DataIC50:  7nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed