BDBM50072077 CHEMBL3407866

SMILES OC(=O)c1cc(ncn1)-c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=FPVPSYCVUOIXCH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50072077   

TargetKynurenine 3-monooxygenase(Mus musculus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  6nMAssay Description:Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  72nMAssay Description:Inhibition of KMO in human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  600nMAssay Description:Antagonistic activity against Histamine H2 receptor expressed as the charge of receptor sensitivity was determined at pH 7.4More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  33nMAssay Description:Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human KMOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  105nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed