BDBM50076137 (S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-4-methyl-pentanoic acid::CHEMBL285129

SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O

InChI Key InChIKey=UVIFZTCJDBHNKJ-FQEVSTJZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50076137   

LigandPNGBDBM50076137((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  6.10E+3nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076137((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  4.60E+4nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076137((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed