BDBM50078448 3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-propionic acid::3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-propionic acid(L-709780)::CHEMBL32960::L-709780
SMILES OC(=O)CCNC(=O)c1ccc2CN(CCC3CCNCC3)C(=O)c2c1
InChI Key InChIKey=YAAYYZAARZCUQN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50078448
Affinity DataKd: 550nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
TargetIntegrin alpha-2/beta-3(Homo sapiens (Human))
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine
Curated by ChEMBL
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Antagonist activity at integrin alpha2beta3-mediated aggregation in ADP-stimulated human plateletsMore data for this Ligand-Target Pair
Affinity DataKd: 550nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of 10 uM ADP-induced human gel filtered platelet aggregation with 0.1 mg/mL human fibrinogenMore data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding affinity against alpha IIb beta3 integrin in the presence of L-736622.More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of ADP-mediated platelet aggregation in human gel-filtered plateletsMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair