BDBM50079362 CHEMBL3417009::US9663465, 9

SMILES COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCC2)CC1

InChI Key InChIKey=FTRZTHFGTILUPE-UHFFFAOYSA-N

Data  8 KI  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50079362   

Target5-hydroxytryptamine receptor 4(GUINEA PIG)
CERMN

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]GR113808 from human 5-HT4R membrane in Tris buffer assessed as inhibitory constant measured after 60 mins by filter binding metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  7.10nMAssay Description:Prior to these competition studies, a series of saturation curves were performed in order to check whether the pharmacological parameters Kd, Bmax an...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]-GR113808 from recombinant human 5-HT4BR expressed in membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  10nMAssay Description:Agonist activity at 5-HT4R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]GR113808 from human 5-HT4 receptor expressed in Chem-1 cell membrane incubated for 60 mins by radiometric scintillation counting ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  16nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in human Jurkat cell membranes after 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataIC50:  16nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and by DTNB reagent based...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataIC50:  16nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataIC50:  16nMAssay Description:Mixed type competitive inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataIC50:  63nMAssay Description:Acetylcholinesterase extracted from human erythrocytes (buffered aqueous solution, ≧500 units/mg, Sigma Aldrich) is diluted in a 20 mM HEPES bu...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataEC50:  11nMAssay Description:Activity at 5-HT4R (unknown origin) expressed in COS7 cells assessed as increase in sAPPalpha releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataIC50:  16nMAssay Description:Inhibition of human erythrocyte AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate by Ellman' methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
CERMN

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataIC50:  3.53E+3nMAssay Description:Inhibition of equine serum BuChE pre-incubated for 5 mins before butyrylthiocholine iodide substrate by Ellman' methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed