BDBM50084621 BMN 673::Talazoparib
SMILES Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1
InChI Key InChIKey=HWGQMRYQVZSGDQ-HZPDHXFCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50084621
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataKi: 0.580nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataKi: 0.850nMAssay Description:Inhibition of human PARP2 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Inhibition of PARP2 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.580nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 3.20nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 0.5 hrs by fluorescenc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-tagged human full length PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) a...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataKd: 1.10nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataKd: 3.30nMAssay Description:Binding affinity to PARP2 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 24nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 0.700nMAssay Description:Binding affinity to PARP4 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 53nMAssay Description:Binding affinity to PARP5a (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to PARP8 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 5.70E+3nMAssay Description:Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP12 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to PARP16 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PARP1 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PARP1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by cell based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataEC50: 2.5nMAssay Description:Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BioMarin Pharmaceutical Inc
Curated by ChEMBL
BioMarin Pharmaceutical Inc
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PARP2 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University
Curated by ChEMBL
Hubei Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair