BDBM50086665 7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydroxy-propoxy}-4H-benzo[1,4]thiazin-3-one::CHEMBL143944

SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1

InChI Key InChIKey=ASDLXXUOHBNMMC-UHFFFAOYSA-N

Data  4 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50086665   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Università di Perugia

Curated by ChEMBL
LigandPNGBDBM50086665(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
Affinity DataKi:  20nMAssay Description:Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brainMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
Università di Perugia

Curated by ChEMBL
LigandPNGBDBM50086665(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
Affinity DataKi: >1.00E+3nMAssay Description:Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...More data for this Ligand-Target Pair
LigandPNGBDBM50086665(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
Affinity DataKi:  4.60E+3nMAssay Description:Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortexMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Canis familiaris)
Università di Perugia

Curated by ChEMBL
LigandPNGBDBM50086665(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
Affinity DataKi:  4.80E+3nMAssay Description:Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lungMore data for this Ligand-Target Pair