BDBM50091822 8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one::CHEMBL301466

SMILES Clc1cc2NC(=O)C3CNCCN3c2cc1Cl

InChI Key InChIKey=PHGWDAICBXUJDU-UHFFFAOYSA-N

Data  2 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50091822   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50091822(8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,...)
Affinity DataKi:  4nMAssay Description:Binding affinity using [125I]-DOI as radioligand with membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50091822(8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,...)
Affinity DataKi:  58nMAssay Description:Binding affinity using [3H]-mesulergine as radioligand with receptor membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptami...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50091822(8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50091822(8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50091822(8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,...)
Affinity DataEC50:  12nMAssay Description:Binding affinity using [3H]-mesulergine as radioligand with receptor membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptami...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed