BDBM50103593 Mephenytoin::Mesantoin::Methoin

SMILES CCC1(NC(=O)N(C)C1=O)c1ccccc1

InChI Key InChIKey=GMHKMTDVRCWUDX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50103593   

TargetCytochrome P450 2J2(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50103593(Mephenytoin | Mesantoin | Methoin)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50103593(Mephenytoin | Mesantoin | Methoin)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 15 to 40 mins in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50103593(Mephenytoin | Mesantoin | Methoin)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103593(Mephenytoin | Mesantoin | Methoin)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed