BDBM50114340 (S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-formyl-3-methyl-butyl)-3-methyl-butyramide::(S)-2-(4-fluorophenylsulfonamido)-3-methyl-N-((S)-4-methyl-1-oxopentan-2-yl)butanamide::CHEMBL288365::N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal::SJA-6017

SMILES CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C)C=O

InChI Key InChIKey=WSJWUIDLGZAXID-HOCLYGCPSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50114340   

TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114340((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Affinity DataIC50:  35nMAssay Description:Tested for inhibitory activity against porcine erythrocyte Mu-calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Sus scrofa)
Senju Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114340((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Affinity DataIC50:  49nMAssay Description:Inhibition of porcein kidney m calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50114340((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCalpain-1 catalytic subunit(Rattus norvegicus)
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50114340((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM50114340((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human Calpain-1 incubated for 60 mins by Bio-Rad protein assay dye reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM50114340((S)-2-(4-Fluoro-benzenesulfonylamino)-N-((S)-1-for...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human erythrocyte mu calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed