BDBM50118824 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid thiophen-3-ylamide; hydrochloride::CHEMBL343521::CHEMBL553824

SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccsc3)c2cc1OC

InChI Key InChIKey=SACBQFMSEKIABM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50118824   

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118824(CHEMBL343521 | CHEMBL553824 | 4-(6,7-Dimethoxy-qui...)
Affinity DataIC50: 560nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118824(CHEMBL343521 | CHEMBL553824 | 4-(6,7-Dimethoxy-qui...)
Affinity DataIC50: 560nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118824(CHEMBL343521 | CHEMBL553824 | 4-(6,7-Dimethoxy-qui...)
Affinity DataIC50: 800nMAssay Description:Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118824(CHEMBL343521 | CHEMBL553824 | 4-(6,7-Dimethoxy-qui...)
Affinity DataIC50: 7.02E+3nMAssay Description:Inhibition of Flt3 autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50118824(CHEMBL343521 | CHEMBL553824 | 4-(6,7-Dimethoxy-qui...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed